N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide

AASraw CGMP qoidalari bo'yicha grammdan N-fenil-4- (3-fenil-1,2,4-tiyadiazol-5-yl) piperazin-1-karboksamid kukuni (CAS 681136-29-8) massa tartibiga sintez va ishlab chiqarish qobiliyatiga ega va kuzatilishi mumkin bo'lgan sifatni nazorat qilish tizimi.

N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid powder tarkibi alkil karbamatlar va alfa-keto heterosiklik aralashmalardan farqli bo'lgan piperazinil-fenil-karbamiddir va kuchli yutuvchi kislotali amid gidrolize (FAAH) inhibitori (IC50s = 34 va 33 nM ning issiqda va insonda) 1 20 mg / kg da anilin va FAAH-poperazinil karbamat ishlab chiqaruvchi karbamidning karbamidning funksionalligini parchalash orqali FAAH faol saytiga kovalent ravishda bog'lanadi.

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N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide video


I.N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide basic Characters:

Ism: N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamide
CAS: 681136-29-8
Tozalik : ≥ 99% (HPLC)
Sinonimlar: JNJ 1661010;N-Phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-1-piperazinecarboxamide;Takeda-25;1-Piperazinecarboxamide, N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)-;JNJ 1661010, >=98%
Molekulyar formulalar: C19H19N5OS
Molekulyar Og'irligi: 365.459
Erish nuqtasi: 240.48
Qaynash nuqtasi: 559.69 mmHg bo'yicha 760 ° C
Zichlik: ~ 1.3 g / cm3
Saqlash harorati: + 4 ° S da saqlansin
Eriydigan: DMSO: ≥ 28mg / ml
Sinov ko'rsatkichi: n20D 1.68
rang: Kristalli qattiq modda
InChI: InChI=1S/C19H19N5OS/c25-18(20-16-9-5-2-6-10-16)23-11-13-24(14-12-23)19-21-17(22-26-19)15-7-3-1-4-8-15/h1-10H,11-14H2,(H,20,25)
InChI Kaliti: BHBOSTKQCZEAJM-UHFFFAOYSA-N


II. N-fenil-4- (3-fenil-1,2,4-tiyadiazol-5-yl) piperazin-1-karboksamid siklida changni ishlatish:

1.Name:

N-fenil-4- (3-fenil-1,2,4-tiyadiazol-5-yl) piperazin-1-karboksamid kukuni, JNJ 166101 chang

2.- N-fenil-4- (3-fenil-1,2,4-tiyadiazol-5-yl) piperazin-1-karboksamid Powder ishlatish bo'yicha qanday ish?

JNJ-1661010 bilan oldindan biriktiriladigan FAAH JNJ1661010 bilan yuqori haroratlarda tezlashtiradigan faol sayt orasidagi o'zaro ta'sirning sekin qaytarilishiga olib keladi. JNJ-1661010 - LC-ESI-MS tomonidan o'rganilayotgan kovalent, mexanizmga asoslangan substrat inhibitoridir. JNJ-1661010, hidrofobik tunelda fenilthiadiazol bilan va FAAH, JNJ-1661010 (20 mg / kg ip) ning hidrofil cho'ntagida fenilurani FAAH ni dozadan keyin kamida 85% ga kamaytiradi, natijada lipid Sichqoncha miyasida etanolamidlar. JNJ-4 doza-mo''tadil Termal Yaralanish (MTI) sichqonlari va rat modelida 1661010 min soniyadan keyin taxminan 90% maksimal samaradorligi bilan sensorli allodinani qaytarib beradi. JNJ-30 (1661010 mg / kg) 20 daqiqada tishli allodiniyani 60.8 daqiqada orqa miya nerv ligati jarohati modelida o'zgartiradi. JNJ-30 (1661010 mg / kg ip) yallig'lanishli og'riqning rat karagenanli modelida 50 min soniyalik dozada hiperaljeziyaning sezilarli darajada susayishini ko'rsatadi.
JNJ-1661010 (20 mg / kg ip) bilan dozalangan kalamushlar 26.9-daqiqada Tmax 0.75 mikrometrli plazma Cmax va 6.04-daqiqada Tmax 2-mM miyasida bir Cmax mavjud. JNJ-1661010 (20 mg / kg ip) miyani FAAH inhibe qiladi va sichqonchani miya to'qimasida AEA darajasini oshiradi.

3. N-fenil-4- (3-fenil-1,2,4-tiyadiazol-5-yl) piperazin-1-karboksamid kukuni haqida ogohlantirish.

Qo'shimcha ma'lumot:

5. N-phenyl-4-(3-phenyl-1,2,4-thiadiazol-5-yl)piperazine-1-carboxamid Powder:

Minimal buyurtma 10grams.
Oddiy miqdor bo'yicha so'rov (1kg ichida) to'lovdan so'ng 12 soat ichida yuborilishi mumkin.
To'liq buyurtma (1kg ichida) to'lovdan so'ng 3 ish joylarida yuborilishi mumkin.

6. N-fenil-4- (3-fenil-1,2,4-tiyadiazol-5-yl) piperazin-1-karboksamid Chang retseptlar:

Batafsil ma'lumot olish uchun mijozlarimizga murojaat qiling (CSR).

7. N-fenil-4- (3-fenil-1,2,4-tiyadiazol-5-yl) piperazin-1-karboksamid kukuni Marketing:

Kelajakda taqdim etilishi kerak.


III. N-fenil-4- (3-fenil-1,2,4-tiyadiazol-5-yl) piperazin-1-karboksamid kukuni HNMR

Biz Aprepitant pudralar, Aprepitant pudrasi, Raw Aprepitant kukuni (170729-80-3) hplc≥98% | AASraw Ar-Ge Reaktivlari


IV. AASraw dan N-fenil-4- (3-fenil-1,2,4-tiadiazol-5-yl) piperazin-1-karboksamid kukuni qanday olinadi?

Biz bilan bog'lanish uchun 1.ga murojaat qilingsurishtiruv tizimi yoki onlayn skypemijozlarga xizmat ko'rsatish vakili (CSR).
2. Biz bilan so'ragan miqdor va manzilni taqdim etish.
3.Custom CSR sizlarga tirnoq, to'lov muddati, kuzatuv raqami, etkazib berish usullari va kiritish borar sanasi (ETA) beradi.
4.Payment amalga oshirildi va mol 12 soat ichida yuboriladi (Buyurtma uchun 10kg ichida).
5.Goods oldi va izoh beradi.


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